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Schwartz Formula:
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The Schwartz formula is a widely used method for estimating creatinine clearance in neonates and children. It provides a simple and practical way to assess renal function in pediatric populations using height and serum creatinine measurements.
The calculator uses the Schwartz formula:
Where:
Explanation: The formula estimates glomerular filtration rate based on the relationship between height, creatinine production, and renal function in neonates.
Details: Accurate assessment of renal function in neonates is crucial for medication dosing, detection of renal impairment, and monitoring of kidney development. The Schwartz formula is specifically validated for pediatric populations.
Tips: Enter height in centimeters, serum creatinine in mg/dL, and select the appropriate k constant based on the infant's birth weight status. All values must be positive and valid.
Q1: What are the different k values used for?
A: k=0.33 is used for low birth weight infants (<2500g), while k=0.45 is used for full term infants with normal birth weight.
Q2: What is the normal CrCl range for neonates?
A: Normal creatinine clearance in neonates typically ranges from 40-65 mL/min/1.73m², increasing with gestational age and postnatal maturation.
Q3: When should this formula be used?
A: The Schwartz formula is specifically designed for neonates and children up to adolescence. It should not be used for adult patients.
Q4: Are there limitations to this formula?
A: The formula may be less accurate in critically ill neonates, those with rapidly changing renal function, or in the presence of significant edema or malnutrition.
Q5: How often should CrCl be monitored in neonates?
A: Frequency depends on clinical context, but typically monitored during hospitalization, when starting nephrotoxic medications, or when renal dysfunction is suspected.