eGFR Calculator From Creatinine

CKD-EPI Equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{Age} \times (1.018 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is eGFR Calculator From Creatinine?

This calculator estimates glomerular filtration rate (GFR) using the CKD-EPI equation based on serum creatinine levels, age, and gender. It provides an accurate assessment of kidney function for clinical evaluation.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{Age} \times (1.018 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( Age \) — Age in years
1.018 — Female multiplier

Explanation: The equation models the non-linear relationship between creatinine and GFR, with gender-specific coefficients for improved accuracy.

3. Importance Of eGFR Calculation

Details: eGFR calculation is essential for detecting kidney dysfunction, staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What Is The Difference Between eGFR And Measured GFR?
A: eGFR is estimated from serum creatinine using equations, while measured GFR involves direct measurement techniques like inulin or iohexol clearance.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is typically ≥90 mL/min/1.73m². Values below 60 mL/min/1.73m² persisting for 3+ months indicate chronic kidney disease.

Q3: When Should Creatinine Be Measured?
A: Morning fasting samples are preferred, but random samples are acceptable. Avoid testing after high-protein meals or strenuous exercise.

Q4: Are There Limitations To This Calculator?
A: Accuracy may be reduced in extremes of age, amputees, pregnant women, and individuals with rapidly changing kidney function or unusual muscle mass.

Q5: Can This Calculator Be Used For Drug Dosing?
A: While useful for initial assessment, precise drug dosing may require measured GFR in specific clinical situations.